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近年来,国外研制了不少新的抗生素,其中有的已通过了动物实验,有的已用于临床,取得了良好的疗效,简介几种。一、头孢吡四唑(Cefpiramide,CPM,Sepatren) CPM是一种新的头孢菌素类抗生素,它有抗葡萄球菌和绿脓杆菌等广谱抗菌作用,特别对绿脓杆菌有良好的抗菌作用。它具有血中浓度高、半衰期长、对β-内酰胺酶稳定等特点。根据临床测定,它的血中半衰期为152分钟,骨髓中的半衰期为105分钟。它能很好地向关节和骨骼移行,所以用于骨关节感染,疗效显著。另有报道指出,由于
In recent years, many new antibiotics have been developed abroad, of which some have passed animal experiments and some have been used in clinical practice and achieved good curative effects. First, cefpiramide (Cefpiramide, CPM, Sepatren) CPM is a new cephalosporin antibiotics, it has anti-Staphylococcus aureus and Pseudomonas aeruginosa and other broad-spectrum antibacterial activity, especially for Pseudomonas aeruginosa has a good antibacterial effect . It has high blood concentration, long half-life, and other characteristics of β-lactamase stability. It has a blood half-life of 152 minutes and a bone marrow half-life of 105 minutes, according to clinical determinations. It can be a good move to the joints and bones, so for bone and joint infections, the effect is significant. Another report pointed out that due