目的探讨羊水栓塞所致产妇猝死的病理学特点,为产科纠纷提供科学依据。方法分析2例羊水栓塞所致产妇猝死病例的尸检HE切片,并进行免疫组化标记观察。结果2例均见肺小动脉及毛细血管内有成团梭形鳞状细胞,并见胎粪小体,1例在子宫血管内见鳞状细胞。免疫组化标记见血管内鳞状细胞Cytokeratin(pan)阳性,CD34阴性。结论羊水栓塞的尸检病理学诊断在产科纠纷的处理中具有重要意义。 Objective To investigate the pathological features of sudden death due to amniotic fluid embolism in order to provide scientific basis for obstetric disputes. Methods Two cases of sudden death from maternal amniotic fluid caused by amniotic fluid embolism were analyzed by autopsy HE sections and observed by immunohistochemistry. RESULTS: In both cases, there was a group of spindle-shaped squamous cells in the pulmonary arterioles and capillaries. Mesentery bodies were also seen. In one case, squamous cells were seen in the blood vessels of the uterus. Cytokeratin (pan) was positive for the intravascular squamous cells and CD34 was negative for immunohistochemistry. Conclusion The autopsy pathological diagnosis of amniotic fluid embolism is of great significance in the management of obstetric disputes.