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目的:研究胃溃宁的抗胃溃疡及抑酸作用。方法:分别采用皮下注射利血平法、shay氏结扎幽门法、乙酸烧灼法等建立大鼠胃溃疡模型,随机分组,模型对照组灌胃给予0.5%羧甲基纤维素钠10ml/kg、药物治疗组分别灌胃给予雷尼替丁50mg/kg、胃康胶囊1.8g/kg和不同剂量的胃溃宁(4.0g/kg,2.0g/kg,1.0g/kg),观察胃溃宁对大鼠胃溃疡面积、胃液分泌量、胃液总酸度及胃蛋白酶活性的影响。结果:胃溃宁4.0g/kg,2.0g/kg,1.0g/kg能明显抑制各型胃溃疡的形成,并有效减小胃溃疡面积,与模型对照组比较,有显著性差异(P<0.01或P<0.05);胃溃宁4.0g/kg,2.0g/kg对于幽门结扎型溃疡,能有效减少胃液分泌量,降低胃液分泌总酸度,抑制胃蛋白酶活性,与模型对照组比较,有明显差异(P<0.01或P<0.05)。结论:胃溃宁对大鼠胃溃疡模型有明显的抗胃溃疡作用。
Objective: To study the anti-gastric ulcer and acid-suppressing effect of Weifuking. Methods: The models of gastric ulcer in rats were established by subcutaneous injection of reserpine, shay’s ligation pylorus method and acetic acid cauterization, respectively. The model group was given gavage with 0.5% sodium carboxymethyl cellulose 10ml / kg, The treatment groups were given ranitidine 50mg / kg, Weikang capsule 1.8g / kg and different doses of sucralfate (4.0g / kg, 2.0g / kg, 1.0g / kg) Gastric ulcer area, gastric secretion, gastric acid total acidity and pepsin activity. Results: Weicunning 4.0g / kg, 2.0g / kg, 1.0g / kg can significantly inhibit the formation of various types of gastric ulcer and effectively reduce the area of gastric ulcer, compared with the model control group, there was a significant difference (P < 0.01 or P <0.05). Weicuning 4.0g / kg, 2.0g / kg for pylorus ligation ulcer, can effectively reduce the secretion of gastric juice, reducing the total acid secretion of gastric juice, inhibition of pepsin activity, compared with the model control group, there are Significant difference (P <0.01 or P <0.05). Conclusion: Weifuking has significant anti-gastric ulcer effect on gastric ulcer model in rats.