The association of gene polymorphism and susceptibility to hepatocellular carcinoma(HCC)has been widely studied in recent years.Gene mutations are closely related to HCC.Understanding and measuring the gene mutations are useful to reduce the incidence of HCC and improve its prognosis. The association of gene polymorphism and susceptibility to hepatocellular carcinoma (HCC) has been widely studied in recent years. Gene mutations are closely related to HCC. Understanding and measuring the gene mutations are useful to reduce the incidence of HCC and improve its prognosis.