超氧化物歧化酶(Superoxide dismuta-se,SOD)是生物体内的一种金属蛋白酶,是超氧自由基的主要清除剂。近年来国内外已开始把SOD作为新型酶制剂应用于临床。有资料表明,~(125)I-SOD经灌胃后能够很快在各主要脏器检测到其放射性,但是以原形物代谢还是以分解产物代谢,目前尚无资料证实。本文应用同位素示踪技术观察人~(125)I-SOD给小鼠灌胃后,小鼠体内吸收、分布情况及吸收形式,为临床口服SOD的可行性提供了实验依据,现报告如下。1 资料和方法 Superoxide dismuta-se (SOD) is a metalloproteinase in the organism that is the main scavenger of superoxide radicals. In recent years, at home and abroad have begun to SOD as a new enzyme preparation used in clinical. Data show that ~ (125) I-SOD can quickly detect radioactivity in major organs after gavage, but the metabolism of protoplasm or decomposition products, there is no data to confirm. In this paper, the isotope tracer technique was used to observe the absorption, distribution and absorption patterns of 125 I-SOD in mice after gavage, which provided the experimental basis for the feasibility of clinical oral SOD. The report is as follows. 1 data and methods