由芳香醛与吗啡啉、氰化钾反应形成的α-芳基-α-(4-吗啉)乙腈,可对α、β不饱和腈或酯进行1,4-加成,生成1,4-酮酸型化合物。此物与肼缩合,再经芳构化即得6-劳基-3(2H)哒嗪酮。后者再经氯化及氨解可得3-氨基-6-芳基哒嗪。本文应用此法合成了15个3-取代哌嗪-6-取代苯基哒嗪类化合物,并初步测定了它们的抗惊(MES)活性。 Addition of α-aryl-α- (4-morpholino) acetonitrile formed by the reaction of aromatic aldehydes with morpholine and potassium cyanide allows the 1,4-addition of α, β-unsaturated nitrile or ester to 1,4 - keto acid compounds. This material and hydrazine condensation, and then by aromatization 6 - Lau-3 (2H) pyridazinone. The latter by chlorination and aminolysis available 3-amino-6-arylpyridazine. In this paper, fifteen 3-substituted piperazine-6-substituted phenyl pyridazines were synthesized and their anti-shock (MES) activities were preliminary assayed.