自咪唑类抗真菌药临床应用以来 ,尤其是酮康唑问世以来 ,研究人员发现通过作用于真菌细胞膜合成可影响细胞色素Ｐ450 的一些酶 ,尤其是其中的 3Ａ4酶 ,可与其他有类似作用的药物发生相互作用 ,二药合用 ,有时可降低抗真菌药的药效 ,有时可提高其药效 ;或反过来被抗真菌药提高或 Since the advent of imidazole antifungal drugs, especially since the advent of ketoconazole, researchers have found that some of the enzymes that affect cytochrome P450, especially the 3A4 enzyme, act on the cell membrane of fungi and work similarly to others Drug interactions, two drugs combined, and sometimes can reduce the antifungal efficacy, and sometimes can improve its efficacy; or in the anti-fungal drugs or increased