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目的探讨血清降钙素原(PCT)检测在恶性肿瘤患者感染诊断中的临床价值。方法将入选病例依据培养结果分为细菌组、真菌组和阴性组,采用ELISA方法检测患者血清PCT水平。结果细菌感染组血清PCT水平明显高于真菌感染组和阴性组,差异有统计学意义(P<0.05);血清PCT阈值分别为0.25ng/mL和0.5ng/mL时,88例细菌组PCT阳性率分别为84.1%(74/88)和63.6%(56/88),真菌组的阳性率均为10.5%(4/38),P<0.05。结论 PCT是有效诊断细菌感染的辅助指标,在鉴别细菌感染和真菌感染时取PCT阈值0.25ng/mL更具临床意义。当PCT<0.25ng/mL时,应考虑真菌或病毒感染。
Objective To investigate the clinical value of serum procalcitonin (PCT) detection in the diagnosis of malignant tumor patients. Methods The selected cases were divided into bacterial group, fungal group and negative group according to the culture results, and serum PCT levels were detected by ELISA. Results The serum PCT level in bacterial infection group was significantly higher than that in fungal infection group and negative group (P <0.05). The serum PCT PCT values were 0.25ng / mL and 0.5ng / The positive rate was 84.1% (74/88) and 63.6% (56/88) in the fungal group, and 10.5% (4/38) in the fungal group, P <0.05. Conclusion PCT is an effective indicator for the diagnosis of bacterial infections. It is of clinical significance to identify the PCT threshold of 0.25 ng / mL in the identification of bacterial and fungal infections. Fungal or viral infections should be considered when PCT <0.25 ng / mL.