论文部分内容阅读
自从1973年发现特异性阿片受体以后,又相继在哺乳动物脑组织内发现和分离出5肽的脑啡肽和31肽的内啡肽。近年来,又相继在脑和外周组织中发现其它内源性阿片样物质。虽然对内源性阿片样物质的研究主要集中在痛的调节方面,但近年来已有越来越多的研究揭示内源性阿片样物质可能是一种重要的神经调质(neuromodulator),它在调节神经、精神、内分泌活动、癫痫、学习记忆、性行为、睡眠觉醒以及呼吸和心血管等生理病理活动中有重要作用。纳洛酮作为阿片受体的特异性拮抗剂,在研究内源性阿片样物质作用中是不可缺少的工具。
Since the discovery of specific opioid receptors in 1973, enkephalin, a 5-peptide, and endorphin, 31 peptide have also been found and isolated in mammalian brain tissue. In recent years, other endogenous opioids have also been found in brain and peripheral tissues one after another. Although the research on endogenous opioids has focused on the regulation of pain, more and more studies in recent years have revealed that endogenous opioids may be an important neuromodulator. Plays an important role in the regulation of neuropsychological, endocrine activities, epilepsy, learning and memory, sexual behavior, sleep arousal, and respiratory and cardiovascular physiological and pathological activities. Naloxone, a specific antagonist of opioid receptors, is an indispensable tool in the study of the role of endogenous opioids.