越来越多的绝经妇女正在接受长周期的激素替代疗法。虽然应用2或3个月孕激素周期表明安全和可接受,但较长周期对子宫内膜增殖、增生过长和阴道突破出血的影响了解不多。连续无对抗雌激素(E)治疗长期使用可造成子宫内膜增生过长和子宫内膜癌发病率增加。相等剂量时所有配方的E用 More and more menopausal women are taking long-term hormone replacement therapy. Although application of 2 or 3 months of the progestogen cycle indicates safety and acceptability, the effect of longer cycles on endometrial proliferation, prolonged hyperplasia and vaginal breakthrough bleeding is poorly understood. Long-term use of continuous non-antagonistic estrogen (E) therapy can lead to prolonged endometrial hyperplasia and increased incidence of endometrial cancer. Equal doses for all formulations of E use