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[目的]观察热毒宁治疗小儿手足口病疗效。[方法]使用随机平行对照方法,将100例门诊及住院患者按病志号抽签法简单随机分为两组。物理降温、保持水电解质的平衡。对照组50例利巴韦林8mg/kg+5%葡萄糖250m L,1次/d,静滴。治疗组50例热毒宁0.7m L/kg+5%葡萄糖250m L,1次/d,静滴。连续治疗5d为1疗程。观测临床症状、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈22例,显效16例,有效10例,无效2例,总有效率96.00%。对照组痊愈18例,显效6例,有效15例,无效11例,总有效率78.00%。治疗组疗效优于对照组(P<0.01)。时间指标治疗组改善优于对照组(P<0.01)。[结论]热毒宁治疗小儿手足口病疗效满意,无严重不良反应,值得推广。
[Objective] To observe the therapeutic effect of Renduining in children with hand-foot-mouth disease. [Methods] Using randomized parallel control method, 100 cases of outpatients and inpatients were randomly divided into two groups randomly according to the method of lot drawing. Physical cooling to maintain the balance of water and electrolyte. Control group, 50 cases of ribavirin 8mg / kg + 5% glucose 250ml, 1 times / d, intravenous infusion. The treatment group, 50 cases of heat toxicity rather 0.7m L / kg + 5% glucose 250m L, 1 times / d, intravenous infusion. Continuous treatment of 5d for a course of treatment. Observed clinical symptoms, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Results] The treatment group cured 22 cases, markedly effective in 16 cases, effective in 10 cases, 2 cases, the total effective rate 96.00%. The control group cured 18 cases, 6 cases markedly effective in 15 cases, ineffective in 11 cases, the total effective rate 78.00%. The treatment group than the control group (P <0.01). Time index treatment group improved better than the control group (P <0.01). [Conclusion] Rendunning treatment of children with hand-foot-mouth disease is satisfactory, no serious adverse reactions, it is worth promoting.