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目的:探讨胃恶性淋巴瘤的临床诊断方法及治疗效果。方法:选择1995年3月到2006年4月在我院进行治疗的12例胃恶性淋巴瘤患者作为研究对象,所有患者均符合临床胃恶性淋巴瘤诊断标准。患者主要的临床表现为上腹痛、消瘦、发热、消化道出血、贫血和恶心呕吐等。所有人群均采用手术和药物联合治疗的治疗方案,研究患者均符合Dawson胃恶性淋巴瘤诊断标准,所有患者均签署知情同意书,愿意参加本研究。结果:对研究人群进行手术后病理学诊断均为临床常见的非何氏杰金氏淋巴瘤。进行有针对性的化疗后进行5年随访,1年死亡病例为1例,生存率为91.67%;3年内死亡病例为1例,生存率为83.33%;5年内死亡病例为2例,生存率为66.67%。其中ⅠEⅡE期5年生存率为87.5%(7/8),ⅢEⅣE期5年生存率为25.0%(1/4)。结论:对胃恶性淋巴瘤的临床诊断率较低,临床表现特异性低,早期诊断采取手术化疗治疗效果较好。
Objective: To investigate the clinical diagnosis and treatment of gastric malignant lymphoma. Methods: Twelve gastric malignant lymphoma patients who were treated in our hospital from March 1995 to April 2006 were selected as the research object. All the patients met the diagnostic criteria of clinical gastric malignant lymphoma. The main clinical manifestations of patients with upper abdominal pain, weight loss, fever, gastrointestinal bleeding, anemia and nausea and vomiting. All patients were treated with surgical and drug combination therapy. All patients met Dawson’s criteria for gastric malignant lymphoma. All patients received informed consent and were willing to participate in the study. RESULTS: Postoperative pathologic diagnosis of the study population was clinically common non-Hertzian lymphoma. After 5-year follow-up after targeted chemotherapy, the 1-year mortality was 1 case, the survival rate was 91.67%; 3 cases died in 1 case, the survival rate was 83.33%; 5-year deaths in 2 cases, the survival rate 66.67%. The 5-year survival rate of ⅠEⅡE was 87.5% (7/8), and the 5-year survival rate of ⅢEⅣE was 25.0% (1/4). Conclusion: The clinical diagnosis of gastric malignant lymphoma is low, the clinical manifestations of low specificity, early diagnosis and treatment of chemotherapy is better.