目的:探讨正常早期妊娠妇女催乳素(PRL)随不同水平血清人绒毛膜促性腺激素β亚单位(β-hCG)的变化规律。方法:采用化学发光免疫测定法检测正常早期妊娠妇女不同孕龄血清β-hCG、PRL水平。结果:当β-hCG≤80 000 IU/L时,PRL随着β-hCG上升同样呈直线上升趋势,其中当β-hCG为70 000￣80 000 IU/L时PRL达到高峰,为76.04±38.97μg/L,提示妊娠早期血清PRL水平随血清β-hCG浓度增高而增加;当β-hCG>80 000 IU/L之后,PRL的变化趋于平稳,无明显的直线上升趋势。结论:建立了正常早期妊娠妇女以β-hCG为参照的PRL变化曲线,为正常早期妊娠妇女的PRL水平提供了合适参考范围。 Objective: To investigate the changes of prolactin (PRL) in normal early pregnancy women with different levels of serum human chorionic gonadotropin β subunit (β-hCG). Methods: Chemiluminescent immunoassay was used to detect the serum levels of β-hCG and PRL in normal pregnant women at different gestational ages. Results: When β-hCG≤80 000 IU / L, the PRL increased linearly with the increase of β-hCG, and reached a peak of 76.04 ± 38.97 at β-hCG of 70 000-80 000 IU / L μg / L, suggesting that PRL levels in early pregnancy increased with the increase of serum β-hCG concentration. When β-hCG> 80 000 IU / L, the changes of PRL tended to be steady with no obvious upward trend. CONCLUSION: The PRL curve of β-hCG in normal early pregnancy women is established, which provides a suitable reference range for PRL levels in normal early pregnant women.