骨肉瘤是最常见的原发性恶性骨肿瘤,好发于10~20岁的青少年,预后差。从上世纪70年代开始,化疗药物开始应用于骨肉瘤的治疗,取得了显著的临床疗效。近年随着肿瘤分子生物学研究的进展,人们已认识到骨肉瘤的基因表达不但决定骨肉瘤的发生、发展和预后,而且也影响了骨肉瘤的化疗疗 Osteosarcoma is the most common primary malignant bone tumor, occurs in adolescents aged 10 to 20 years, the prognosis is poor. From the 70s of last century, chemotherapy drugs began to be applied in the treatment of osteosarcoma and achieved remarkable clinical efficacy. In recent years, with the progress of tumor molecular biology research, it has been recognized that the gene expression of osteosarcoma not only determines the occurrence, development and prognosis of osteosarcoma, but also affects the chemotherapy of osteosarcoma