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目的:观察前列地尔联合更昔洛韦常规治疗带状疱疹的疗效和安全性。方法:120例带状疱疹住院患者随机分为两组各60例。对照组给予更昔洛韦注射液常规治疗;观察组在对照组基础上加用前列地尔注射剂。两组疗程均为12 d。比较两组止疱时间、疼痛缓解时间、皮损痊愈时间,治疗后随访1~3个月,比较两组后遗神经痛(PHN)发病率。结果:两组止疱时间和皮损痊愈时间比较,差异无统计学意义(P>0.05)。观察组疼痛缓解时间、PHN发病率显低于对照组(P<0.05)。结论:前列地尔联合更昔洛韦常规治疗能明显缩短带状疱疹患者的疼痛时间、降低PHN的发病率,且安全性好。
Objective: To observe the curative effect and safety of alprostadil combined with ganciclovir in the routine treatment of shingles. Methods: 120 patients with shingles were randomly divided into two groups of 60 cases. The control group was given ganciclovir injection routine treatment; observation group in the control group based on the use of alprostadil injection. The two courses of treatment were 12 d. The blister time, pain relief time and healing time of the lesions were compared between the two groups. The patients were followed up for 1 to 3 months after treatment. The incidence of postherpetic neuralgia (PHN) was compared between the two groups. Results: There was no significant difference between the two groups in the time of blister healing and the healing of skin lesions (P> 0.05). The observation group pain relief time, PHN incidence was significantly lower than the control group (P <0.05). CONCLUSION: Conventional alprostadil combined with ganciclovir can shorten the pain time and reduce the incidence of PHN in patients with shingles, and its safety is good.