早孕酮是半合成的孕酮(黄体酮)衍生物,多年来用于治疗绝经后晚期乳腺癌病人,药物动力学研究证明大剂量应用是必要的,而且有作者证明大剂量甲孕酮比小剂量缓解率高。作者对40例绝经前晚期乳腺癌患者前瞻性和随机比较应用大剂量甲孕酮和卵巢切除术的效果。所有病例均为首次治疗的晚期病人。两组年龄、活动状况(PS)和主要病变部位大致相似。多数患者(62.5％)有骨转移,且病变仅一处者占70％,22例应用大剂量甲孕酮(剂量1000mg) Progesterone is a semi-synthetic progesterone (progesterone) derivative that has been used for many years to treat postmenopausal patients with advanced breast cancer. Pharmacokinetic studies have demonstrated that high-dose applications are necessary, and the authors have shown that high-dose medroxyprogesterone is smaller than Dose remission rate is high. The authors prospectively and randomly compared the efficacy of high-dose medroxyprogesterone and oophorectomy in 40 patients with premenopausal advanced breast cancer. All cases were advanced patients treated for the first time. The age, activity status (PS), and major lesions were similar in both groups. Most of the patients (62.5%) had bone metastases, and only 70% of them had lesions. In 22 patients, high-dose medroxyprogesterone was used (dose 1000 mg).