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在延缓着床的大白鼠中观察到:宫腔内注入雌二醇抗血清能明显地抑制雌二醇的致着床作用,但是,雌二醇抗血清对cAMP 和cUMP 的致着床作用无明显影响,提示环核苷酸可能不是通过刺激胚泡分泌雌激素而导致着床的。克罗米芬能完全拮抗雌二醇的致着床作用,但对环核苷酸的致着床作用无明显影响,说明环核苷酸不是通过子宫的雌激素受体来发挥作用的。甲氰咪呱使雌二醇的致着床作用明显减弱,但对环核苷酸的致着床作用无显著影响,这说明在环核苷酸的致着床作用中可能没有组织胺参与。消炎痛能明显地抑制雌二醇及两种环核苷酸的致着床作用,这说明在环核苷酸的致着床作用中可能有前列腺素参与。
Observed in rats with delayed implantation: intrauterine injection of estradiol antiserum significantly inhibited the role of estradiol implants, but estradiol antisera on cAMP and cUMP induced bed effect Significant effect, suggesting that cyclic nucleotides may not stimulate the blastocyst secretion of estrogen caused implantation. Clomiphene could completely antagonize the effect of estradiol on implantation, but had no significant effect on the implantation effect of cyclic nucleotides, suggesting that cyclic nucleotides did not act through the estrogen receptor of the uterus. Ciclacyl significantly attenuated the lethal effect of estradiol, but did not have any significant effect on the carding effect of cyclic nucleotides, suggesting that histamine may not be involved in the putative role of cyclic nucleotides. Indomethacin significantly inhibits the lethal effect of estradiol and two cyclic nucleotides, suggesting prostaglandins may be involved in the putative role of cyclic nucleotides.