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目的 :探讨吉西他滨联合顺铂内科保守方法治疗老年晚期胃癌患者的效果。方法 :选取2011年1月-2013年6月间收治的110例胃癌术后行化疗的住院患者,随机分为观察组以及对照组,对照组予以吉西他滨治疗,观察组联合用顺铂治疗,比较两组患者的近期疗效、不良反应情况。结果 :两组患者均进行了2-4个疗程的化疗,平均为3个疗程。观察者的治疗有效率为40%,明显高于对照组的20%,组间比较差异有统计学意义,两组化疗的主要毒性为骨髓抑制以及恶性呕吐反应,而外周神经毒性为顺铂所特有,其余并发症如Hb下降、PLT下降、肝毒性、肾毒性等比较无明显差异,且均为轻度,不影响下周期的化疗。结论 :吉西他滨联合顺铂应用于晚期老年胃癌化疗疗效优于单独应用于吉西他滨,建议使用其应用于多程化疗失败的晚期胃癌患者。
Objective: To investigate the effect of gemcitabine plus cisplatin in conservative treatment of elderly patients with advanced gastric cancer. Methods: One hundred and ten hospitalized patients with postoperative chemotherapy for gastric cancer who were admitted to our hospital from January 2011 to June 2013 were randomly divided into observation group and control group. The control group was treated with gemcitabine and the observation group was treated with cisplatin. The two groups of patients with short-term efficacy, adverse reactions. Results: Two groups of patients underwent 2-4 courses of chemotherapy with an average of 3 courses of treatment. Observer’s treatment efficiency was 40%, significantly higher than 20% of the control group, the difference between the two groups was statistically significant, the main toxicity of two groups of chemotherapy for bone marrow suppression and malignant vomiting, and peripheral neurotoxicity cisplatin Unique, the remaining complications such as Hb decreased, PLT decreased, hepatotoxicity, nephrotoxicity and other no significant difference, and are mild, does not affect the next cycle of chemotherapy. Conclusion: Gemcitabine plus cisplatin is superior to gemcitabine alone in the treatment of advanced gastric cancer. It is recommended to use gemcitabine combined with cisplatin in advanced gastric cancer patients with failed multi-course chemotherapy.