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目的:研究海藻酸微球及由海藻酸微球、果胶、HPMC组成的骨架片中苯基偶氮苯的释放特性.方法:海藻酸微球通过喷雾-凝聚法制得,苯基偶氮苯 (PAA)作为疏水性模型药物通过吸附法被微球载运.制备了由海藻酸微球、果胶、HPMC组成的骨架片.测定了海藻酸微球及骨架片中苯基偶氮苯的释放.为进一步探讨药物释放机制,进行了骨架片的溶胀实验.结果:微球中PAA的释放依赖于释放介质,其中在水中释放不完全,在人工胃肠液中呈延缓到肠内释放的特性.在骨架片中也观察在人工胃肠液中的延缓释放行为.果胶酶有一定的加速骨架片释放的的作用.释放度和溶胀实验数据均证明骨架片为溶胀控制.结论:海藻酸微球可以作为一种疏水性药物的延缓释放载药系统.“,”AIM:To investigate the release characteristics of insoluble drug from alginate macroparticles and matrix tablets.METHOD:Alginate microparticles were manufactured by spray-coagulation method. 4-phenylazoaniline (PAA) was selected as a insoluble model drug. PAA was loaded into alginate microparticles by adsorption method. Matrix tablets composed of PAA loaded alginate microparticles, HPMC (K4M), pectin were directly compressed. The release experiments of PAA from alginate microparticles and matrix tablets were conducted in different medium. To elucidate the release mechanism, swelling experiments were conducted, the erosion front, diffusion front and swelling front of tablets were measured.RESULT:The release of PAA from the microparticles was found to depend upon the release medium and incomplete %in vitro% release in deionized water was observed. Delayed release of PAA from both microparticles and matrix tablets in simulated gastrointestinal (GI) fluid were observed. Pectinase could increase the release rate of PAA from the matrix tablets. Both release data and swelling data indicated that the release of PAA from matrix tablets was controlled by swelling process.CONCLUSION: Alginate microparticles could be useful in delayed release of insoluble drugs.