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由于观察性研究更能体现真实的临床实践,具有随机临床试验无法比拟的全面代表性和临床适用性优势,可补充和加强随机临床试验所确立的证据体系,尤其适用于在大型、异质性、复杂慢性疾病患者人群中评估治疗结局。观察性研究证据体系在对T1DM和T2DM患者胰岛素治疗的理解中发挥了重要作用。本文回顾了长效胰岛素类似物地特胰岛素的主要观察性研究证据,佐证其对糖尿病患者的疗效、安全性和耐受性。
Because observational studies better reflect real clinical practice and have the advantages of full representation and clinical applicability that are not comparable to randomized clinical trials, they complement and reinforce evidence systems established in randomized clinical trials and are particularly useful in large, heterogeneous , Assessment of treatment outcome in a population of patients with complex chronic diseases. Observational evidence systems have played an important role in the understanding of insulin therapy in patients with T1DM and T2DM. In this review, we review the main observational evidence of insulin as a long-acting insulin analogue and demonstrate its efficacy, safety and tolerability in diabetic patients.