论文部分内容阅读
炎症性肠病的病因和发病机理目前仍不清楚,一些学者认为CIC与其发病有关。为了明确CIC与IBD和慢性结肠炎之间的相互关系,我们检测了6例IBD,44例慢性结肠炎以及3例慢性结肠炎伴回肠末段淋巴滤泡增生者的血清CIC值,结果提示:慢性结肠炎组血清CIC值高于正常对照组(P<0.01);慢性结肠炎伴回肠未段淋巴滤泡增生组血清CIC值高于正常对照组(P<0.001);IBD组血清CIC值低于慢性结肠炎组(P<0.01);也低于正常对照组(P<0.05)。IBD组CIC下降被认为是免疫复合物沉积于结肠组织所致,并激活补体,引起了免疫损伤。上述结论尚待进一步进行免疫组织化学研究。
Etiology and pathogenesis of inflammatory bowel disease is still unclear, some scholars believe that CIC and its pathogenesis. In order to clarify the relationship between CIC and IBD and chronic colitis, we examined the serum CIC values of 6 IBD patients, 44 chronic colitis patients and 3 patients with chronic colitis with terminal ileum follicular hyperplasia. The results suggest that: The serum CIC of chronic colitis group was higher than that of normal control group (P <0.01). The serum CIC value of chronic colitis with ileum follicular hyperplasia group was higher than that of normal control group (P <0.001) In chronic colitis group (P <0.01); also lower than the normal control group (P <0.05). The decrease in CIC in the IBD group is thought to be caused by the deposition of immune complexes in the colon and activates complement, causing immune damage. The above conclusion remains to be further studied by immunohistochemistry.