奥美拉唑为质子泵抑制剂(PPls)。奥美拉唑及其他质子泵抑制剂现已广泛用于治疗胃及十二指肠溃疡、胃食管反流性疾病、卓一艾氏综合征等。奥美拉唑常见不良反应为恶心、胀气、腹泻、便秘、上腹痛等。但近年时有关于奥美拉唑引起急性间质性肾炎并发展为急性肾衰的报道。1992年Ruf Omeprazole is a proton pump inhibitor (PPls). Omeprazole and other proton pump inhibitors are now widely used in the treatment of gastric and duodenal ulcers, gastroesophageal reflux disease, Zhuo Yi Ehrlich syndrome. Omeprazole common adverse reactions are nausea, flatulence, diarrhea, constipation, abdominal pain and so on. However, in recent years, there have been reports of omeprazole-induced acute interstitial nephritis and development of acute renal failure. 1992 Ruf