论文部分内容阅读
目的:探讨宫颈小细胞癌(SC-CC)的临床特征及其影响因素。方法:回顾性分析我院1999-01-01-2009-08-30收治的10例SCCC患者的临床及病理资料。ⅠB和ⅡA8例期患者均行广泛子宫切除+盆腔淋巴结清除术。术后病理示,6例患者发现盆腔内淋巴结转移,伴发腺癌、低分化鳞癌各1例。8例患者均行术后放化疗,其中术前行辅助性放疗、化疗及放化疗各者1例。结果:随访至2010-10,6例术后病理淋巴结转移阳性的患者均已死亡,平均生存时间16个月;2例淋巴结阴性的患者均无瘤生存,生存时间19个月。晚期患者中1例行放化疗治疗,1例因年龄较大仅行放射治疗;2例患者均已死亡,生存时间分别为12和8个月。结论:SCCC早期即可发生远处转移,预后较差。采用综合治疗是提高治疗疗效的关键,既使是晚期病例,通过积极治疗亦可延长生存期。
Objective: To investigate the clinical characteristics of cervical small cell carcinoma (SC-CC) and its influencing factors. Methods: The clinical and pathological data of 10 patients with SCCC admitted to our hospital from January 1999 to January 2009 were retrospectively analyzed. ⅠB and Ⅱ A8 cases of patients underwent extensive hysterectomy + pelvic lymph node dissection. Postoperative pathology, 6 patients found pelvic lymph node metastasis, associated with adenocarcinoma, poorly differentiated squamous cell carcinoma in 1 case. All 8 patients underwent postoperative radiotherapy and chemotherapy, of which preoperative adjuvant radiotherapy, chemotherapy and radiotherapy and chemotherapy in 1 case. Results: All the patients who had positive pathological lymph node metastasis were followed up from October 2010 to June 2010 with a mean survival time of 16 months. Two patients with negative lymph node had no tumor-free survival and the survival time was 19 months. One patient in advanced stage received radiotherapy and chemotherapy, and one patient underwent radiotherapy due to age. Two patients died and their survival time was 12 and 8 months respectively. Conclusion: The early stage of SCCC can occur distant metastasis with poor prognosis. The use of comprehensive treatment is to improve the therapeutic effect of the key, even in advanced cases, can also extend the survival of active treatment.