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目的探讨沙眼衣原体（Ct）感染与自然流产的关系及可能的致病机理。方法对39例自然流产患者、33例正常生育及39例正常妊娠妇女，分别检测宫颈管粘液Ct—DNA、血清内特异性衣原体抗体（AcAb）及血清内抗子宫内膜抗体（EMAb）。结果自然流产患者与正常生育及妊娠组比较，宫颈管粘液Ct—DNA检出率显著增高（P＜0．05），而AcAh检出率无明显差异（P＞0．05）；但自然流产次数≥3次者，其宫颈管粘液Ct—DNA和AcAb检出率皆显著高于流产次数＜3次者及正常生育及妊娠组；自然流产患者血清内特异性EMAb检出率显著高于正常妊娠组；其中ACAb阳性的自然流产患者EMAb检出率显著高于AcAb阴性的自然流产患者。结论生殖器Ct感染是自然流产的病因之一，尤其与反复多次的自然流产有关；其致病机理可能与诱发子宫内膜局部组织的自身免疫反应有关。
Objective To investigate the relationship between Chlamydia trachomatis (Ct) infection and spontaneous abortion and its possible pathogenesis. Methods Ct-DNA, AcAb in serum and anti-endometrial antibody in serum (EMAb) were detected in 39 cases of spontaneous abortion, 33 cases of normal pregnancy and 39 normal pregnant women. Results In spontaneous abortion patients, the detection rate of Ct-DNA in cervical mucus was significantly higher than that in normal fertility and pregnancy group (P <0.05), while the detection rate of AcAh was no significant difference (P> 0.05). However, spontaneous abortion The detection rate of Ct-DNA and AcAb in cervical mucus was significantly higher than that in abortion <3 times and in normal fertility and pregnancy group. The detection rate of specific EMAb in spontaneous abortion patients was significantly higher than that in normal Pregnancy group. The detection rate of EMAb in patients with ACAb-positive spontaneous abortion was significantly higher than that in patients with AcAb-negative spontaneous abortion. Conclusions Ct infection of genitalia is one of the causes of spontaneous abortion, especially related to repeated spontaneous abortion. Its pathogenic mechanism may be related to the autoimmune reaction induced by local tissue of endometrium.