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AIM:To investigate the expression and prognostic value of CCL2 in gastric cancer,as well as its relationshipwith tumor hypoxia.METHODS:Tumor tissues from 68 gastric cancer patients(GC)were analyzed,and the expression of CCL2and hypoxia-inducible factor 1 alpha(HIF-1α)in tumortissues was detected by immunohistochemistry.Statistical evaluations that were used included univariate logrank tests of Kaplan-Meier curves and multivariate Coxregression model analysis.RESULTS:CCL2 was highly expressed in 66.2%(45/68)of gastric cancer specimens.The distribution of CCL2expression in tumor tissue was consistent with thatof HIF-1α.Patients with high CCL2 expression in GChad a lower overall survival rate[50.6 mo(95%CI:44.44-56.93)vs 64.6 mo(95%CI:60.27-68.94),P=0.013].CONCLUSION:CCL2 expression correlates closely with HIF-1αexpression in gastric cancer.CCL2 may be an independent prognostic marker for GC.
AIM: To investigate the expression and prognostic value of CCL2 in gastric cancer, as well as its relationship with tumor hypoxia. METHODS: Tumor tissues from 68 gastric cancer patients (GC) were analyzed, and the expression of CCL2 and hypoxia-inducible factor 1 alpha HIF-1α) in tumortissues was detected by immunohistochemistry. Statistical evaluations that were used included univariate logrank tests of Kaplan-Meier curves and multivariate Cox regression model analysis .RESULTS: CCL2 was highly expressed in 66.2% (45/68) of gastric cancer specimens. The distribution of CCL2expression in tumor tissue was consistent with that of HIF-I [alpha] .Patients with high CCL2 expression in GChad a lower overall survival rate [50.6 mo (95% CI: 44.44-56.93) vs 64.6 mo (95% CI: 60.27-68.94 ), P = 0.013] .CONCLUSION: CCL2 expression correlates closely with HIF-1αexpression in gastric cancer. CCL2 may be an independent prognostic marker for GC.