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随着60年代以来蛋白质化学和一些特殊物质的形态学定位技术的飞速发展,除了搞清楚一些经典的消化道激素如促胰液素、胃泌素和胆囊收缩素的化学结构外,还发现了多种由散在于胃肠道粘膜和胰腺组织中的分泌细胞所产生的生物活性物质,总数不下20余个,主要是肽类,也有一些是胺类和嘌呤类物质。近年来一个重要的发现是,一些在消化道发现的肽类物质也被发现存在于中枢和外周神经中,而一些原来在脑内被确定的
With the rapid development of morphological positioning technology of protein chemistry and some special substances since the 1960s, in addition to clarifying the chemical structures of some classic gastrointestinal hormones such as secretin, gastrin and cholecystokinin, more The total number of bioactive substances produced by secretory cells scattered in the mucosa of the gastrointestinal tract and in the pancreas is less than 20, mostly peptides, and some are also amines and purines. An important finding in recent years is that some of the peptides found in the digestive tract have also been found in central and peripheral nerves, whereas some of those originally identified in the brain