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目的分析医院感染铜绿假单胞菌的分布特点及耐药情况,为临床治疗和合理用药提供依据。方法对医院2013年至2015年临床分离的945株铜绿假单胞菌,采用法国梅里埃公司生产的VITEK-2Compact全自动微生物分析仪做鉴定和药敏试验,WHONET5.6软件对数据进行统计分析。结果 2013年1月至2015年12月,收集临床分离菌共945株,感染常见部位为呼吸道和泌尿系统,发生率较高的科室是老干部保健所、ICU、脑外科。铜绿假单胞菌对哌拉西林/他唑巴坦耐药率最低(<7%),对左氧氟沙星、环丙沙星、阿米卡星、头孢吡肟耐药率<24.9%,对亚胺培南和美罗培南耐药率呈逐年上升的趋势,耐药率已高达41.5%。结论铜绿假单胞菌感染以呼吸道为主,对常用抗菌药物均产生不同程度的耐药性,临床应加强对该菌的监测,合理使用抗菌药物。
Objective To analyze the distribution characteristics and drug resistance of Pseudomonas aeruginosa in hospital and provide basis for clinical treatment and rational drug use. Methods 945 strains of Pseudomonas aeruginosa clinically isolated from 2013 to 2015 in the hospital were identified and susceptible tested by the VITEK-2 Compact Automatic Microbial Analyzer manufactured by Merial France. The data were analyzed by WHONET 5.6 software . Results From January 2013 to December 2015, a total of 945 clinical isolates were collected. The common infection sites were respiratory tract and urinary system. The departments with higher incidence were veteran cadre health center, ICU and brain surgery. The resistance rate of Pseudomonas aeruginosa to piperacillin / tazobactam was the lowest (<7%), the drug resistance rate to levofloxacin, ciprofloxacin, amikacin and cefepime was <24.9% The rates of resistance to penem and meropenem are increasing year by year with the rate of resistance up to 41.5%. Conclusions Pseudomonas aeruginosa infection is mainly respiratory tract, which produces different degrees of resistance to commonly used antimicrobial agents. Clinical monitoring of this strain should be strengthened and antibiotics should be used reasonably.