【摘 要】
：
目的马钱子是传统的镇痛中药之一,马钱子碱(又名布鲁生)是马钱子镇痛的有效成分,但外周镇痛机制研究较少,本文通过痛行为检测和单纤维自发放电手段,观察马钱子碱在外周损伤区中的镇痛作用机制。方法 建立慢性压迫损伤模型 (CCI),利用机械缩足反射阈值(PWT)和热缩足潜伏期(PWL)检测大鼠的疼痛行为学变化;记录起步点单纤维自发放电检测 马钱子碱对放电频率的影响。结果 与溶剂组相比,外周损伤区局部注射马钱子碱后 PWT 和 PWL 显著增加(P<0.01),预先 注射非特异性钾通道阻断剂四乙基铵(TEA)
【机 构】
：
陕西中医药大学陕西省针药结合重点实验室
论文部分内容阅读
目的马钱子是传统的镇痛中药之一,马钱子碱(又名布鲁生)是马钱子镇痛的有效成分,但外周镇痛机制研究较少,本文通过痛行为检测和单纤维自发放电手段,观察马钱子碱在外周损伤区中的镇痛作用机制。方法 建立慢性压迫损伤模型 (CCI),利用机械缩足反射阈值(PWT)和热缩足潜伏期(PWL)检测大鼠的疼痛行为学变化;记录起步点单纤维自发放电检测 马钱子碱对放电频率的影响。结果 与溶剂组相比,外周损伤区局部注射马钱子碱后 PWT 和 PWL 显著增加(P<0.01),预先 注射非特异性钾通道阻断剂四乙基铵(TEA)
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