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目的:探讨妊娠期高血压疾病血脂代谢特点及CRP变化,了解脂代谢紊乱在妊娠期高血压疾病发病机制中的作用。方法:随机抽取住院分娩孕产妇妊娠期高血压疾病患者253例分为3组,妊娠期高血压组98例,轻度子痫前期组85例,重度子痫前期组70例;同时选择无妊娠合并症与并发症健康孕妇300例作为对照组,检测孕妇血脂、载脂蛋白、BMI及CRP水平进行比较。结果:妊娠期高血压疾病3个组TC、TG和LDL-C水平均高于对照组,而HDL-C水平均低于对照组,且差异有统计学意义(P<0.05)。妊娠期高血压疾病组BMI明显高于对照组,且随病情加重BMI逐渐升高(P<0.01)。妊娠期高血压疾病组CRP与BMI、TC、TG、LDL水平正相关(P<0.05),与HDL-C负相关(P<0.05)。结论:妊娠期高血压疾病存在明显的血脂代谢及CRP水平异常。
Objective: To investigate the characteristics of blood lipid metabolism and CRP in hypertensive disorders of pregnancy, and to understand the role of lipid metabolism disorder in the pathogenesis of hypertensive disorders of pregnancy. Methods: A total of 253 hospitalized pregnant women with gestational hypertension were randomly divided into 3 groups, 98 cases of hypertensive pregnancy group, 85 cases of mild preeclampsia group and 70 cases of severe preeclampsia group. At the same time, no pregnancy Complications and complications of healthy pregnant women 300 cases as a control group, detection of serum lipids, apolipoproteins, BMI and CRP levels were compared. Results: The levels of TC, TG and LDL-C in hypertensive disorder complicating pregnancy were higher than those in control group, while the levels of HDL-C were lower than those in control group (P <0.05). The BMI in gestational hypertension group was significantly higher than that in control group, and the BMI gradually increased with the progression (P <0.01). CRP was positively correlated with BMI, TC, TG and LDL levels in gestational hypertension (P <0.05) and negatively correlated with HDL-C (P <0.05). Conclusion: There is obvious blood lipid metabolism and abnormal CRP level in hypertensive disorder complicating pregnancy.