多发性抽动秽语综合征,又称抽动秽语综合征,是一种于儿童期起病,临床上以头面部、肢体或躯干部的多发性肌肉抽动与爆破状不自主发声或猥亵言语等为特征的疾病。在美国,该征的患病率约0.1～1％,估计有20余万患者。本文旨在对该征的病因和治疗学进展作一概述。 一 病因学 本征确切病因虽未完全明了,但近年来随着遗传学、电生理学、神经药理学和神经生化等方面的进展,对该征的病因学有了一些新的认识,主要在以下几个方面: Multiple Tourette’s Syndrome, also known as Tourette’s Syndrome, is a childhood onset characterized by multiple muscular twitching and explosive involuntary speech or obscenity in the head and face, limbs or trunk The disease. In the United States, the prevalence of the syndrome is about 0.1 to 1%, an estimated 200,000 patients. This article aims to summarize the etiology and treatment progress of the syndrome. Although the exact etiology of etiology is not fully understood, in recent years, with the advances in genetics, electrophysiology, neuropharmacology and neurobiochemistry, there have been some new insights into the etiology of the etiology, mainly in the following several aspects: