糖尿病肾病是糖尿病的严重并发症和主要死亡原因 ,以早期肾小管高灌注、肾小球肥大、系膜区扩张、基底膜增厚 ,晚期肾小球毛细血管腔闭塞、硬化为特征。在美国 ,糖尿病肾病已成为终末期肾脏疾病首位病因 ,约占 35 8% 〔1〕 ;在我国台湾 ,糖尿病肾病已占终末期肾病的 2 6% ,日 Diabetic nephropathy is a serious complication of diabetes and the main cause of death, characterized by early tubular hyperperfusion, glomerular hypertrophy, mesangial area expansion, basement membrane thickening, late glomerular capillary occlusion and sclerosis. In the United States, diabetic nephropathy has become the leading cause of end-stage renal disease, accounting for 35 8% [1]; in Taiwan, diabetic nephropathy has accounted for 26% of end-stage renal disease, Japan