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目的研究子宫颈癌与子宫内膜癌患者ABCF2表达与临床的关系(临床分期、组织类型、分级、预后)。方法对267例浸润性子宫颈癌、103例子宫内膜癌、5例增生性子宫内膜、5例分泌期子宫内膜、5例正常子宫颈上皮组织进行免疫组织化学染色,观察ABCF2的表达情况,并与临床情况比较。结果子宫颈癌患者中有149(55.8%)表达ABCF2;全部生存者ABCF2阴性表达长于阳性表达者(P=0.0069)。有统计学意义的生存预后因素包括:ABCF2表达、年龄、进展期。多元化危险因素对比试验表明ABCF2阳性表达是一个独立的影响预后的因素。在子宫内膜癌患者中72例(69.9%)细胞质中ABCF2表达,然而,ABCF2表达与临床因素无明显联系。结论 ABCF2的表达在子宫颈癌中可能是一个有意义的标志物,ABCF2阳性表达是一个独立的影响预后的因素,在子宫内膜癌中无明显意义。
Objective To study the relationship between ABCF2 expression and clinical status in patients with cervical cancer and endometrial cancer (clinical stage, histological type, grade and prognosis). Methods 267 cases of invasive cervical cancer, 103 cases of endometrial cancer, 5 cases of proliferative endometrium, 5 cases of secretory endometrium, 5 cases of normal cervical epithelial tissue immunohistochemical staining to observe the expression of ABCF2 , And compared with the clinical situation. Results 149 (55.8%) of patients with cervical cancer expressed ABCF2; all survivors were longer than those with positive expression of ABCF2 (P = 0.0069). There were statistically significant survival prognostic factors include: ABCF2 expression, age, progression. A comparative study of multiple risk factors indicates that positive ABCF2 expression is an independent prognostic factor. In the endometrial cancer patients 72 cases (69.9%) of cytoplasmic ABCF2 expression, however, ABCF2 expression and clinical factors were not significantly linked. Conclusion The expression of ABCF2 may be a significant marker in cervical cancer. The positive expression of ABCF2 is an independent prognostic factor, which is not significant in endometrial carcinoma.