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目的:为了进一步探讨大肠癌的化疗疗效,完善临床用药方法。方法:根据2012年5月~2013年5月间在我院接受化疗的98例大肠癌患者的临床治疗资料,对三类临床常规性药物:5-氟尿嘧啶类药物,亚叶酸钙类药物,草酸铂类药物的治疗效果进行对比。结果:单纯使用5-氟尿嘧啶的用药有效率为35.5%,存活中位为17.3个月;单纯使用亚叶酸钙有效率为18.1%,存活中位为16.3个月;单纯使用草酸铂有效率为26.9%,生存中位为20.4个月。3种药物的疗效比对无统计学差异性(P均<0.05)。其中5-氟尿嘧啶使用范围最广,以5-氟尿嘧啶为基础药物交替使用其他两种药物治疗结果有明显改善。结论:大肠癌病变范围较大,使用化疗控制较难,单纯性使用一种药物治疗结果不明显,以5-氟尿嘧啶为基药联合用药,或其他药物联合用药治疗结果较为理想。
Objective: In order to further explore the chemotherapy effect of colorectal cancer, improve the clinical medication method. Methods: According to the clinical data of 98 patients with colorectal cancer undergoing chemotherapy in our hospital from May 2012 to May 2013, the clinical data of three kinds of clinical routine drugs, such as 5-fluorouracil, leucovorin, oxalic acid Platinum drugs compared the efficacy of treatment. Results: The effective rate of 5-fluorouracil treatment was 35.5%, and the median survival time was 17.3 months. The effective rate of leucovorin alone was 18.1% and the median survival time was 16.3 months. The effective rate of oxaliplatin alone was 26.9 %, The median survival was 20.4 months. There was no significant difference between the three drugs (P <0.05). The most extensive use of 5-fluorouracil, 5-fluorouracil-based drugs alternating with the other two kinds of drug treatment results have been significantly improved. CONCLUSIONS: The range of colorectal cancer lesions is large. It is difficult to control with chemotherapy. Simple treatment with one drug is not obvious. Combined with 5-Fluorouracil or other drugs, the results are satisfactory.