AIM:To study the prevalence of Barrett’s esophagus inChinese and its correlation with gastroesophageal reflux.METHODS:This study was carried out in a large prospectiveseries of 391 patients who had undergone upper endoscopy.The patients were divided into 3 groups according to theposition of squamocolumnar junction(SCJ).Refluxesophagitis(RE)and its degree were recorded.Intestinalmetaplasia(IM)in biopsy specimen was typed according tohistochemistry and HE and alcian blue(pH2.5)stainingseparately.Results correlating with clinical,endoscopic,andpathological data were analysed.RESULTS:The prevalence of IM endoscopically appearingLong-segment Barrett’s Esophagus(LSBE)was 26.53%,Short-segment Barrett’s Esophagus(SSBE)was 33.85% andgastroesophageal junction(GEJ)was 34.00%.IM increasedwith age of above 40 years old and no difference was foundbetween male and female.Twelve were diagnosed asdysplasia(7 low -grade,5 high-grade),16 were diagnosedas cardiac adenocarcinoma and 1 as esophagealadenocarcinoma.The more far away the SCJ moved upwardabove GEJ,the higher the prevalence and the more severethe RE were.CONCLUSION:There was no difference of the prevalenceof IM in different places of SCJ,and IM increased with ageof above 40 years old.It is important to pay attention todysplasia in the distal esophagus and gastro-esophagealjunction,and adenocarcinoma is more common in cardiathan in esophagus.BE is a consequence of gastroesophagealreflux disease. AIM: To study the prevalence of Barrett’s esophagus in Chinese and its correlation with gastroesophageal reflux. METHODS: This study was carried out in a large prospective series of 391 patients who had undergone upper endoscopy. The patients were divided into 3 groups according to theposition of squamocolumnar junction (SC) .Refluxesophagitis (RE) and its degree were recorded.Intestinal metaplasia (IM) in biopsy specimen was typed according tohistochemistry and HE and alcian blue (pH2.5) stainingseparately. Results of correlating with clinical, endoscopic, andpathological data were analysed.RESULTS : The prevalence of IM endoscopically appearingLong-segment Barrett’s Esophagus (LSBE) was 26.53%, Short-segment Barrett’s Esophagus (SSBE) was 33.85% andgastroesophageal junction (GEJ) was 34.00%. IM increasedwith age of above 40 years old and no difference was foundbetween male and female.Twelve were diagnosed as dysplasia (7 low-grade, 5 high-grade), 16 were diagnosed as cardiac adenocarcinoma and 1 as esophagealadenocar cinoma.The more far away the SCJ moved upwardabove GEJ, the higher the prevalence and the more severethe RE were .CONCLUSION: There was no difference of the prevalence of IM in different places of SCJ, and IM increased with ageof above 40 years old.It is important to pay attention to todysplasia in the distal esophagus and gastro-esophageal junction, and adenocarcinoma is more common in cardiathan in esophagus.BE is a consequence of gastroesophageal reflux disease.