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目的探讨脑胶质瘤术后3年生存率的影响因素。方法回顾性分析2008至2010年收治的30例脑胶质瘤患者3年生存率及其影响因素,对患者的性别、年龄、术前KPS评分、肿瘤大小、切除程度、病理分级、放疗时间及方式与预后的相关性进行单因素分析,然后对有统计学意义的因素进一步行Cox多因素分析。结果 30例脑胶质瘤患者3年生存率为73.3%,年龄、病理分级、术前KPS评分、手术切除程度是影响脑胶质瘤术后预后(3年生存率)的相关因素(P<0.05或P<0.01)。年龄>60岁与≤60岁(44.4%vs 85.7%,P<0.05)、低级别与高级别(86.4%vs 37.5%,P<0.01)、术前KPS评分≥70分与<70分(82.6%vs 42.9%,P<0.05)、手术全切与残余(83.3%vs 33.3%,P<0.05)等相关因素差异均有统计学意义。结论年龄>60岁、病理分级高级别、术前KPS评分<70分及手术切除有残余为影响脑胶质瘤术后预后的危险因素。
Objective To investigate the influencing factors of 3-year survival rate of glioma after operation. Methods The 30-year survival rate and its influencing factors in 30 patients with gliomas admitted from 2008 to 2010 were retrospectively analyzed. The gender, age, preoperative KPS score, tumor size, resection degree, pathological grade, radiotherapy time and Way and prognosis of univariate analysis, and then statistically significant factors further Cox multivariate analysis. Results The 30-year survival rate of 30 glioma patients was 73.3%. The age, pathological grade, preoperative KPS score and degree of surgical resection were the related factors that affected the prognosis (3-year survival rate) of gliomas after operation (P < 0.05 or P <0.01). (60.4% vs 85.7%, P <0.05), low and high grade (86.4% vs 37.5%, P <0.01), preoperative KPS score ≥70 and <70 (82.6 % vs 42.9%, P <0.05). There were significant differences in the related factors such as total and residual surgery (83.3% vs 33.3%, P <0.05). Conclusion The age> 60 years old, high grade of pathological grade, preoperative KPS score <70 and remnant of surgical excision are the risk factors affecting the postoperative prognosis of glioma.