普鲁卡因作为局部麻醉药和静脉复合麻醉中的主要药物,在临床上广泛应用。然而,大剂量普鲁卡因可发生中毒,其主要表现为惊厥、呼吸抑制和循环衰竭~1。对于前二者,经过大量的基础实验和临床研究,已找到了较好的防治方法~(23)。但普鲁卡因中毒引起的循环衰竭,仍无有效的防治措施。Sadove等指出,大剂量普鲁卡因中毒时,对心脏的抑制作用是致死的主要原因。因此,开展对普鲁卡因心脏毒性的防治研究,有更为重要的实用意义。我们在大鼠的实验中,发现1,2-丙二醇能 Procaine as a local anesthetic and intravenous compound anesthesia in the main drug, widely used in clinical practice. However, high-dose procaine can be toxic and predominantly convulsions, respiratory depression and circulatory failure ~ 1. For the first two, after a lot of basic experiments and clinical studies, we have found a better prevention and cure method ~ (23). However, procaine poisoning caused by circulatory failure, there is no effective prevention and treatment measures. Sadove, etc. pointed out that the high dose of procaine poisoning, the inhibition of the heart is the main cause of death. Therefore, to carry out prevention and treatment of procaine cardiotoxicity has more important practical significance. In our experiments in rats, we found that 1,2-propanediol can