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目的:观察并探讨联合检测超敏C反应蛋白(hs-CRP)与降钙素原(PCT)水平对老年脓毒血症的早期诊断价值。方法:选择自2014年6月至2015年9月本院接诊的老年脓毒血症患者64例,为观察组;并选取同期入院排除毒血症的健康老年体检者64例为对照组。其中观察组按照严重程度分为轻中度组28例,和重度组36例。比较各组患者hs-CRP、PCT水平以及APACHE Ⅱ和序贯器官衰竭估计评分(SOFA)。结果:观察组hsCRP、PCT水平、APACHE Ⅱ和SOFA评分分别为(49.2±13.6)mg/L、(1.98±0.54)μg/L、(12.4±2.8)分和(2.6±0.7)分,对照组为(12.4±3.5)mg/L、(0.42±0.12)μg/L、(3.2±0.7)分和(1.2±0.4)分,观察组hs-CRP、PCT水平均明显高于对照组,且APACHE Ⅱ和SOFA评分也明显高于对照组(P<0.05);轻中度组PCT、APACHE Ⅱ和SOFA评分明显低于重度组(P<0.05),两组hs-CRP相比,差异不具有统计学意义(P>0.05)。结论:hs-CRP与PCT水平对老年脓毒血症具有明确的诊断价值,而PCT水平还能指示患者的严重程度。
Objective: To observe and explore the value of combined detection of hs-CRP and PCT in the early diagnosis of senile sepsis. Methods: Sixty-four elderly patients with sepsis admitted to our hospital from June 2014 to September 2015 were selected as the observation group. Sixty-four healthy elderly patients who were admitted to the hospital during the same period to exclude toxemia were selected as the control group. According to the severity of the observation group, 28 cases were divided into mild and moderate group, and 36 cases in severe group. The levels of hs-CRP, PCT, and APACHE II and SOFA were compared between groups. Results: The scores of hsCRP, PCT, APACHE Ⅱ and SOFA in the observation group were (49.2 ± 13.6) mg / L, (1.98 ± 0.54) μg / L, (12.4 ± 2.8) and (2.6 ± 0.7) (12.4 ± 3.5) mg / L, (0.42 ± 0.12) μg / L, (3.2 ± 0.7) and (1.2 ± 0.4) points respectively. The hs-CRP and PCT levels in the observation group were significantly higher than those in the control group Ⅱ and SOFA scores were significantly higher than those in the control group (P <0.05). The scores of PCT, APACHE Ⅱ and SOFA in mild to moderate group were significantly lower than those in severe group (P <0.05). There was no statistical difference in hs-CRP between the two groups Significance (P> 0.05). Conclusions: hs-CRP and PCT levels have a clear diagnostic value in senile sepsis, and PCT level can also indicate the severity of the patients.