【摘 要】
：
目的探讨骨化三醇胶丸联合替米沙坦片治疗早期糖尿病肾病(DN)的疗效。方法 70例早期糖尿病肾病患者,随机分为对照组与观察组,各35例。对照组采用替米沙坦片治疗,观察组采用骨
【机 构】
：
034000,忻州市人民医院内分泌科
论文部分内容阅读
目的探讨骨化三醇胶丸联合替米沙坦片治疗早期糖尿病肾病(DN)的疗效。方法 70例早期糖尿病肾病患者,随机分为对照组与观察组,各35例。对照组采用替米沙坦片治疗,观察组采用骨化三醇胶丸联合替米沙坦片治疗。比较两组患者的临床疗效;治疗后肾功能及血糖各项指标、炎性因子水平变化情况。结果观察组治疗总有效率为94.29%,明显高于对照组的77.14%,差异具有统计学意义(P<0.05)。观察组治疗后超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)水平均明显低于对照组,差异具有统计学意义(P<0.05)。观察组治疗后尿白蛋白排泄率(UAER)、24 h尿蛋白定量水平均明显低于对照组,差异具有统计学意义(P<0.05);两组血肌酐(Scr)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)水平比较,差异无统计学意义(P>0.05)。结论骨化三醇胶丸联合替米沙坦片治疗早期糖尿病肾病的疗效显著,能有效减轻肾功能损害,降低机体炎性反应,具有积极的临床意义。
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