睑缘炎相关角结膜病(BKC)是指由睑缘炎引起的角结膜病变,临床表现主要有结膜充血、结膜乳头及滤泡增生、泡性角结膜炎、边缘角膜炎、角膜点状上皮糜烂、角膜溃疡、角膜瘢痕及角膜新生血管,严重可致角膜穿孔.BKC临床症状及体征较为复杂,易误诊,贻误治疗.临床中常采用的治疗方法包括热敷、睑板腺按摩等物理疗法,人工泪液、抗生素、糖皮质激素、非甾体类药物、免疫抑制剂等眼用制剂进行药物治疗,严重者需接受角膜移植手术治疗.本文就BKC的病因、发病机制、诊断和防治等方面的研究进展作一综述.“,”Blepharokeratoconjunctivitis (BKC) is a chronic inflammatory disorder and can be defined as lid margin blepharitis accompanied by conjunctivitis and keratopathy.Typical clinical characteristics of BKC consisted of conjunctival hyperemia,papillary hyperplasia follicles,punctate keratitis,marginal keratitis,corneal punctuate epithelial erosion,corneal ulcer,corneal scar and vascularization,corneal perforation.The clinical symptoms and signs of BKC are complicated,which can lead to misdiagnose.The physiotherapy of BKC includes eyelid hygiene,meibomian glands massage and warm compresses;the drug treatment of BKC includes artificial tear,topical antibiotics,corticosteroids,nonsteroidal anti-inflammatory drugs (NSAIDs),immunosuppressants and so on.Corneal transplantation is required for the severe BKC patients.The etiology,pathogenesis,diagnosis and management of BKC was reviewed in this artcle.