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目的探讨社区综合干预对新发生2型糖尿病患者胰岛功能的影响。方法通过社区糖尿病普查,将新发现的50例T2DM患者随机分为干预组27例和对照组23例,进行为期2年的社区综合干预和对照观察。观察中期和结束后,检测两组患者的血压、体重指数(BMI)、腰臀围比(WHR)、血糖(PG)、糖化血红蛋白(HBA1C)、血胰岛素(INS),利用HOMA模型中胰岛素抵抗指数(Homa-IR)、β细胞功能指数(Homa-β或HBCI)以及β细胞2h分泌功能指数(△I120/△G120)评价胰岛功能。结果干预组血压、WHR、BMI、2hINS、Homa-β与对照组比较差异无显著性;而干预组PG、HBA1C和Homa-IR则明显降低,对照组则升高;干预组△I120/△G120升高、对照组降低,P值分别是:0.01、0.000、0.015、0.014。结论社区综合干预可以改善新发生T2DM患者的胰岛功能。
Objective To investigate the effect of community-based intervention on the islet function in newly diagnosed type 2 diabetic patients. Methods A total of 50 newly diagnosed T2DM patients were randomly divided into intervention group (n = 27) and control group (n = 23) through community diabetes screening. Two-year comprehensive community intervention and controlled observation were performed. Blood pressure, body mass index (BMI), WHR, blood glucose (PG), HbA1c, insulin (INS) were measured at the end of the observation period and after the end of the study. Insulin resistance (Homa-IR), β-cell function index (Homa-β or HBCI) and β-cell 2h secretion function index (△ I120 / △ G120) Results There were no significant differences in the blood pressure, WHR, BMI, 2hINS and Homa-β between the intervention group and the control group, while the levels of PG, HBA1C and Homa-IR in the intervention group were significantly lower than those in the control group Increased, the control group decreased, P values were: 0.01,0.000,0.015,0.014. Conclusion Comprehensive community intervention can improve the islet function in newly diagnosed T2DM patients.