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奥美拉唑(omeprazole,OPZ)是强力长效胃酸分泌抑制剂,本文介绍薄层色谱(TLC)光密度法测定肠衣丸中的OPZ,由于它在酸性介质中不稳定,最佳流动相系统由氯仿/甲醇/25%氨水(97.5:2.5:1)组成。OPZ的Rf值为0.46。色谱板上的斑点用光密度计在302nm波长处扫描。面积信号对0.42～1.68μg
Omeprazole (OPZ) is a potent and potent gastric acid secretion inhibitor. In this paper, the TLC method is used to determine OPZ in enteric coated pills. Because of its instability in acid medium, the best mobile phase system It consists of chloroform / methanol / 25% aqueous ammonia (97.5: 2.5: 1). The Rf value of OPZ is 0.46. The spot on the plate is scanned with a densitometer at a wavelength of 302 nm. Area signal of 0.42 ~ 1.68μg