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对世居平原的健康男性青年急进高原低氧环境后血浆β -内啡肽 (β -EP)的变化水平与高原病的发生进行了探讨。结果表明 ,进入高原前血浆 β-EP浓度越高 ,急性高原反病发病率越高。血浆β -EP的浓度与发病率呈正相关 ,血浆β -EP水平的变化与海拔高度呈正相关 ,急性高原反应可被纳洛酮所反转。提示 ,急性缺氧引起血浆 β -EP升高 ,可能是急性高山病的重要因素。血浆β -EP的变化水平可作为缺氧程度和诊断急性高山反应的一项重要指标 ,亦可作为评价急性高山反应轻重的一项参考指标。β -EP可能参与高山反应的病理生理过程
The level of plasma β - endorphin (β - EP) and the incidence of altitude sickness in healthy plain young highland hypoxia environment were explored. The results showed that the higher plasma β-EP concentration before entering the plateau, the higher the incidence of acute altitude sickness. The plasma concentration of β -EP was positively correlated with the incidence. The change of plasma β-EP level was positively correlated with the altitude. The acute altitude sickness could be reversed by naloxone. Prompt, acute hypoxia caused by plasma β -EP increased, may be an important factor in acute mountain sickness. The level of plasma β-EP changes can be used as an important indicator of hypoxia and diagnosis of acute alpine reactions, as well as a reference index for evaluating the severity of acute alpine reactions. β-EP may participate in the pathophysiological process of alpine response