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目的评价卡前列素氨丁三醇(欣母沛)在预防剖宫产后妊娠者阴道分娩产后出血中的疗效与安全性。方法 96例剖宫产后妊娠经阴道分娩产妇,随机分为观察组46例和对照组50例,观察组在胎儿娩出后即给予静脉滴注缩宫素20U,同时臀部深部肌内注射欣母沛250μg;对照组在胎儿娩出后即给予静脉滴注缩宫素20U。比较2组产后出血率及产后2h出血量。结果观察组产后出血1例(2.17%),对照组产后出血6例(12.00%),2组比较差异无统计学意义(P>0.05);观察组比对照组产后2h平均出血量减少[(207.34±78.88)vs(263.64±87.49)ml,P<0.05],差异有统计学意义。结论欣母沛用于预防剖宫产后阴道分娩产后出血安全有效,在一定程度上可降低产后出血的发生率。
Objective To evaluate the efficacy and safety of carboprost tromethamine in the prevention of postpartum hemorrhage due to vaginal delivery in cesarean section. Methods Ninety-six women with vaginal delivery after cesarean section were randomly divided into observation group (n = 46) and control group (n = 50). The observation group received intravenous injection of oxytocin 20U after the delivery of the fetus, Pei 250μg; control group was given after intravenous infusion of oxytocin 20U fetus. The incidence of postpartum hemorrhage and postpartum 2h bleeding were compared between the two groups. Results Postpartum hemorrhage was observed in 1 case (2.17%) in observation group and 6 cases (12.00%) in post-partum control group, with no significant difference between the two groups (P> 0.05) 207.34 ± 78.88) vs (263.64 ± 87.49) ml, P <0.05], the difference was statistically significant. Conclusion Xin Mapei used to prevent postpartum cesarean section postpartum hemorrhage safe and effective, to a certain extent, reduce the incidence of postpartum hemorrhage.