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目的 探讨影响双侧乳癌患者临床特点及预后的因素。方法 回顾性分析 1975年 11月～ 2 0 0 2年 1月行乳腺癌根治性手术 184 5例中经病理组织学证实的双侧原发性腺癌 (bilateralprimarybreastcancer ,BPBC) 5 2例的临床资料。其中同时性双侧乳腺癌 11例 (2 1.2 % ) ,异时性双侧乳腺腺癌 4 1例 (78.8% ) ,接受手术、放疗、化疗等单一或综合治疗。分析乳腺癌的多种预后因素与术后生存率的关系。结果 原发肿瘤的大小、浸润淋巴结的数目、正确治疗和两侧乳腺癌的间距时间等均影响预后。三、五、十年的生存率各为 90 %(19/ 2 1)、71.4 % (15 / 2 1)和 6 6 .7% (14 / 2 1)。结论 正确治疗的双侧乳腺癌仍有较高的五年生存率 ,两侧乳腺癌之间的间隔时间是主要的预后因素 ,与生存率呈正相关。早期诊断和治疗第二原发癌仍是提高生存率的关键。
Objective To investigate the clinical characteristics and prognosis of patients with bilateral breast cancer. Methods The clinical data of 522 cases of bilateral primary primary adenocarcinoma (BPBC) confirmed by histopathology from November 1975 to January 2002 in radical surgery of breast cancer were retrospectively analyzed. Including simultaneous bilateral breast cancer in 11 cases (2 1.2%), heterotopic bilateral breast adenocarcinoma 41 cases (78.8%), undergoing surgery, radiotherapy, chemotherapy and other single or comprehensive treatment. To analyze the relationship between multiple prognostic factors of breast cancer and postoperative survival rate. Results The size of the primary tumor, the number of infiltrating lymph nodes, the correct treatment and the interval between the two sides of breast cancer all affect the prognosis. Three, five and ten years’ survival rates were 90% (19/2), 71.4% (15/2) and 6.6% (14/2) respectively. Conclusion Correct treatment of bilateral breast cancer still has a high five-year survival rate, the interval between the two sides of the breast cancer is the main prognostic factor, and the survival rate was positively correlated. Early diagnosis and treatment of the second primary cancer is still the key to improving survival.