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目的 研究胃腺癌及配对淋巴结转移灶中上皮性钙粘素 (E -cd)和增殖细胞核抗原 (PCNA)的表达及意义。方法 应用免疫组织化学法检测 2 0例正常胃黏膜、2 0例异型增生、1 0 9例胃癌及淋巴结转移灶中E -cd和PCNA表达。结果 E -cd和PCNA在异型增生、胃癌及淋巴结转移灶中阳性表达率分别为 85 % (1 7/2 0 )、40 .37% (44/1 0 9)、2 3 .85 % (2 6/1 0 9)和 2 5 % (5/2 0 )、74.31 % (81 /1 0 9)及 77.98% (85/1 0 9)三者之间有显著差异 (P <0 .0 1 )。E -cd和PCNA表达与胃腺癌Lauren分型和预后显著相关。结论 E -cd和PCNA可反映胃腺癌的生物学特性 ,是预测患者预后有价值的指标
Objective To study the expression and significance of epithelial cadherin (E-cd) and proliferating cell nuclear antigen (PCNA) in gastric adenocarcinoma and paired lymph node metastasis. Methods The expressions of E-cd and PCNA in 20 cases of normal gastric mucosa, 20 dysplasia and 109 cases of gastric cancer and lymph node metastasis were detected by immunohistochemistry. Results The positive expression rates of E-cd and PCNA in dysplasia, gastric cancer and lymph node metastasis were 85% (1 7/2 0), 40.37% (44/1 0 9) and 23 5% (2 6/1 0 9) and 25% (5/2 0), 74.31% (81/109) and 77.98% (85/1 0 9) respectively (P <0.01 ). E-cd and PCNA expression were significantly correlated with Lauren’s classification and prognosis of gastric adenocarcinoma. Conclusion E-cd and PCNA can reflect the biological characteristics of gastric adenocarcinoma and is a valuable index to predict the prognosis of patients