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目的:研究肿瘤坏死子因子-α(TNF-α)在人体的生理及病理作用。方法:用放射免疫分析法测定正常人及病人血清TNF-α值,并对各组值进行比较分析。结果:①不同年龄正常人之间血清TNF-α值有明显差异(p<0.01);②患者血清TNF-α值均显著高于相应对照组(p<0.01),但成人患者又显著低于新生儿和儿童患者(p<0.01);③脑血管病患者血清TNF-α值高于其它患者组,并且在治疗后血清TNF-α值有明显下降。结论:①血清TNF-α值可作为肿瘤、感染、脑血管病等疾病的一种检测指标;②TNF-α在人体中有重要的生理及病理作用,值得进一步深入研究。
Objective: To study the physiological and pathological effects of tumor necrosis factor-α (TNF-α) in the human body. Methods: The levels of serum TNF-α in normal subjects and patients were determined by radioimmunoassay. The values of each group were compared and analyzed. Results: ① There was a significant difference in serum TNF-α between normal subjects (p <0.01); ② The level of serum TNF-α in patients was significantly higher than that in corresponding control group (p <0.01) Neonates and children (p <0.01); ③ serum TNF-α in patients with cerebrovascular disease was higher than other groups, and the serum TNF-αdecreased significantly after treatment. Conclusions: (1) Serum TNF-α can be used as a detection index for diseases such as tumor, infection and cerebrovascular disease. (2) TNF-α has important physiological and pathological effects in human body and deserves further study.