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目的探讨血清铁蛋白水平检测在糖尿病神经源性膀胱(DNB)患者诊断中的意义。方法 142例2型糖尿病患者根据是否并发神经源性膀胱分为并发组(n=63)和单纯组(n=79),同时,在体检中心选取健康者作为对照组(n=70),利用全自动生化仪对研究对象血糖、血脂相关指标及铁蛋白(SF)进行检测,评估胰岛素抵抗指数和胰岛β功能指数,利用多因素非条件Logistic回归分析对DNB相关危险因素进行分析。结果并发组患者FPG、HbA1c、TC、TG和LDL-C均高于单纯组,且单纯组高于对照组,差异均有统计学意义(P<0.05);并发组患者SF和胰岛素抵抗指数均高于单纯组,且单纯组高于对照组,差异均有统计学意义(P<0.05),并发组和单纯组患者Fins和胰岛β功能指数均高于对照组,差异均有统计学意义(P<0.05);Pearson相关分析显示,血清SF水平与FPG、HbA1c、TC、TG和胰岛素抵抗指数均呈正相关。(r=0.392、0.417、0.504、0.387和0.354,均P<0.05);多因素Logistic回归分析显示,病程、年龄、SF、FPG、HbA1c、Fins和TG均是DNB发生的相关危险因素(均P<0.05)。结论 DNB患者出现血清SF水平升高,SF与糖尿病患者糖脂代谢关系密切,可作为DNB早期发现的监测指标之一。
Objective To investigate the significance of serum ferritin level in the diagnosis of diabetic neurogenic bladder (DNB). Methods 142 patients with type 2 diabetes mellitus (T2DM) were divided into two groups according to whether they were complicated with neurogenic bladder (n = 63) or simple group (n = 79). At the same time, healthy controls were selected as the control group (n = 70) The automatic biochemical analyzer was used to test the blood glucose, blood lipid related index and ferritin (SF), to evaluate the insulin resistance index and pancreatic β function index. The multivariate non-conditional Logistic regression analysis was used to analyze the risk factors of DNB. Results The levels of FPG, HbA1c, TC, TG and LDL-C in the concurrent group were significantly higher than those in the simple group and those in the simple group were significantly higher than those in the control group (P <0.05). The SF and insulin resistance index (P <0.05). The functional indexes of Fins and islet β were significantly higher in patients with simple and complicated group than those in simple group (P <0.05), and the difference was statistically significant (P < P <0.05). Pearson correlation analysis showed that serum SF levels were positively correlated with FPG, HbA1c, TC, TG and insulin resistance index. (r = 0.392,0.417,0.504,0.387 and 0.354, all P <0.05) .Multivariate Logistic regression analysis showed that the course of disease, age, SF, FPG, HbA1c, Fins and TG were all risk factors of DNB <0.05). Conclusion Serum SF levels are elevated in patients with DNB. SF is closely related to glucose and lipid metabolism in patients with diabetes mellitus, which may be used as one of the indicators of early detection of DNB.