论文部分内容阅读
目的 研究血管紧张素转换酶基因多态性在慢性肾功能不全患者中的分布及意义。方法 检测 88例慢性肾功能不全患者的基因型 ,以 87例正常人为对照。结果 与对照组相比 ,基因型及等位基因频率分布 ,在失代偿期患者无差异 ,在肾衰期和尿毒症期患者存在差异 ,其中DD型频率升高 ,各为 5 7.1%和 6 1.5 %对 2 4.1% (P <0 .0 1,P <0 .0 0 1) ;II型频率在尿毒症期下降为 13 .9%对 3 1.1%(P <0 .0 5 )。结论 基因多态性与肾疾病进展有关 ,DD型是高危因素 ,基因型的检测可做为判断预后及指导治疗的指标
Objective To investigate the distribution and significance of angiotensin converting enzyme gene polymorphism in patients with chronic renal failure. Methods The genotypes of 88 patients with chronic renal failure were detected, and 87 normal controls were used as controls. Results Compared with the control group, genotype and allele frequency distribution showed no difference in patients with decompensation, and there were differences in patients with renal failure and uremia. The frequency of DD type was increased by 51.1% and 6 1.5% vs 2 4.1% (P <0.01, P <0.001); Type II frequency decreased from 13.9% vs 31.1% (P <0.05) during uremia. Conclusion The genetic polymorphism is related to the progress of renal disease. DD is the risk factor, and the detection of genotype can be used as an index to judge prognosis and guide treatment