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采用手术方法造成家兔慢性充血性有心衰竭,发现心衰兔心房提取物的利钠利尿活性明显降低(与对照相比,P<0.01)。电镜观察发现,心衰兔心房肌细胞含心钠素的特殊颗粒数显减少。生物学活性检测与形态学观察结果一致。在家兔实验性心力衰竭时,心房肌内心钠素的减少可能系大量心钠素排入血液的结果。
Surgical methods were used to induce chronic congestive heart failure in rabbits and it was found that the natriuretic activity of atrial extracts in heart failure rabbits was significantly reduced (P<0.01 compared to control). Electron microscopy revealed that the number of special particles containing atrial natriuretic peptide in atrial myocytes of heart failure rabbits was significantly reduced. The biological activity test was consistent with the morphological observations. In experimental heart failure in rabbits, the reduction of atrial natriuretic peptide in the atrial myocardium may be the result of a large number of atrial natriuretic peptides discharged into the blood.