人型乳头状瘤病毒（HPV）可诱发皮肤和粘膜的良性肿瘤、癌前期症和癌肿，近期在结肠癌细胞系已检出HPV，并提出结肠、直肠腺瘤和癌肿是连续过程的假说，采取腺瘤供作观察癌肿发生中基因改变的极好模型。作者收集109例腺瘤的石蜡包埋组织（包括管状腺瘤38例、管状绒毛状腺瘤40例和绒毛状腺瘤31例），应用聚合酶链反应（PCR）和Southern印渍 Human papilloma virus (HPV) can induce benign tumors, precancerous lesions, and cancers of the skin and mucous membranes. HPV has recently been detected in colon cancer cell lines and it is proposed that colon, rectal adenoma, and cancer are continuous processes. The hypothesis is that an adenoma is used as an excellent model for observing the genetic changes in the occurrence of cancer. The authors collected paraffin-embedded tissue from 109 adenomas (including 38 tubular adenomas, 40 tubular villous adenomas, and 31 villous adenomas) using polymerase chain reaction (PCR) and Southern blotting.